ABSTRACT
Objective To investigate the human chorionic gonadotropin (β-HCG) and its free β-subunit (fβ-HCG) content change,to observe the 48 hours multiplication factor,combined with progesterone value in the diagnosis of adverse pregnancy for clinical diagnosis and treatment of adverse pregnancy to provide guidance.Methods The chemiluminescence technique was used to detect serum β-HCG,fβ-HCG and progesterone levels in early adverse pregnancy.According to pregnancy,the pregnant women were divided into threatened abortion group (65 cases),missed abortion group (43 cases) and ectopic pregnancy group (62 cases),while 60 normal pregnant women were selected as control group.Theβ-HCG,fβ-HCG,progesterone levels and 48 hours multiplication factor were measured.The results combined with the pregnancy outcomes were analyzed.Results The serum β-HCG,fβ-HCG,progesterone levels in the threatened abortion group,missed abortion group and ectopic pregnancy group were (15 385 ± 4 350) IU/L,(77.2 ± 21.3) IU/L,(20.8 ± 6.3) μg/L; (1 584 ± 362) IU/L,(119.3 ± 34.1) IU/L,(6.1 ± 3.7) μg/L; (1 459 ± 493) IU/L,(132.1 ± 35.7) IU/L,(5.7 ± 3.4) μg/L; the β-HCG levels 48 hour doubling rates in three groups were (1.52 ±0.51),(0.21 ±0.26),(0.13 ±0.08) ;threatened abortion group β-HCG and 48 hours multiplication factor,progesterone levels and missed abortion and ectopic pregnancy group were significantly different (t =7.41,5.17,6.89,all P ＜ 0.05) ; there were no significant differences between missed abortion group and ectopic pregnancy group (t =0.851,0.782,0.864,all P ＞ 0.05) ;fβ-HCG in threatened abortion group was average 30mIU/mL lower than the missed abortion group and ectopic pregnancy group,the difference was statistically significant (t =6.18,P ＜ 0.05).With miscarriage success fβ-HCG showed a decreasing trend.Conclusion β-HCG and progesterone combined 48 hours multiphcation ratio values for monitoring miscarriage of important guiding significance for the diagnosis of missed abortion and ectopic pregnancy has important reference value trimester β-HCG 48 hour doubling rate of less than 0.5,abortion increased risk;fβ-HCG data descending indicates miscarriage treatment is effective.